Endocrine Abstracts

Low-T3 syndrome (euthyroid sick syndrome) develops in critically ill patients. Due to the catabolic state, accompanying critical illnesses, enhanced oxidative damage to macromolecules is expected to occur in subjects suffering from the low-T3 syndrome.The study aimed at evaluating the level of lipid peroxidation products in blood serum, collected from critically ill patients with the low-T3 syndrome and at estimating the ...

Acute presentation: 46 year old patient was admitted as an emergency with vomiting, hypotension and serum cortisol of 26 nmol/L indicative of adrenal failure. Despite previous history of panhypopituitarism he was found to be hyperthyroid (free T4 6.32 ng/dL (0.93-1.7), free T3 22.21 pg/mL (1.8-4.6)).Past Medical History: He was fit & well till the age of 45. Eight months prior to this hospitalisation he presented with diabetes insipidus and was found...

29-year old woman was admitted with tetany & severe hypocalcaemia despite treatment with high dose alpha-calcidiol (6 micrograms/day) and Calcium (8.0 g/day).PMH: Six years previously she had subtotal thyroidectomy for non-toxic goitre in another Department. Postoperatively she required Thyroxine, but was lost to formal endocrine follow-up. Five years later she presented with abdominal discomfort and occasional diarrhoea. Investigations performed by ...

Background: ACTH concentrations remain typically elevated in patients with Addison’s disease. We present a case of an extremely potent oral contraceptive pill (OCP) induced increase in total cortisol resulting in inhibition of ACTH secretion that was normalized on OCP withdrawal.Case Presentation: A 20-year old female was diagnosed with Addison’s disease [cortisol 1.59 µg/dl, ACTH>500 pg/ml (0-65)] and...

Background: Amiodarone-induced thyrotoxicosis (AIT) is sometimes very difficult to treat. Pulse methylprednisolone in addition to oral steroids appears effective in treatment of AIT, but effects of such treatment may be transient.Presentation of The Case: A 65 year old man was admitted our Department because of drug-resistant AIT. He had a history of atrial fibrillation, treated with amiodarone since 2019, and NSTEMI myo...

Background: Amiodarone-induced thyrotoxicosis is sometimes extremely difficult to treat necessitating emergency thyroidectomy with perioperative risks including possible thyroid storm. We obtained near normalization of free T3 (FT3) by pulse Methylprednisolone prior to thyroidectomy for drug-resistant Amiodarone-induced thyrotoxicosis.Case Description: A 56 year old man (BMI 29.7 kg/m2), with history atrial flutter/fibrillation, episodes of fa...

Goitre incidence in school-aged children evaluated by the use of ultrasonography (US), apart from reflecting urine iodine concentration and percentage of households consuming iodized salt, is an essential indicator for assessing iodine intake in a given area. The position in which the US examination is being performed can also be an important problem in terms of its result interpretation. The aim of the study was to examine what is the difference between the thyroid volume mea...

Background: Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of therapeutic dose of 131I. Unfortunately, administration of radioisotope in diagnostic dose may decrease further radioiodine uptake – the phenomenon called ‘thyroid stunning’. We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein lev...

Background: Self-administration of anabolic steroids among bodybuilders is an underestimated problem, often not admitted by patients.Case presentaation: A 19 year old male (planning to study medicine!) presented with gynaecomastia, general malaise and erectile problems. Investigations revealed acute hepatitis: ALT 2125 U/L [Ref. range (RR)<45] and hypogonadotropic hypogonadism: LH – 1.6 IU/L [RR: 1.5-9.3], testosterone 0.214 ng/mL [RR: 2.49-8.36...

Introduction: GH therapy in children with normal GH peak in stimulation tests (GHST) is still a matter of discussion. Recently, GH deficiency (GHD) has been defined as secondary IGF1 deficiency (IGFD), however GHST still remain the main procedure in diagnosing GHD.The aim of present study was to compare GH therapy effectiveness in the patients with normal results of GHST (normGH) and with isolated partial GHD (pGHD), with respect to IGF-I secretion befor...